Blood Microbiota and Cancer: Cell Wall-Deficient L-Forms of Bacteria and Fungi as Cancer-Promoting Environment

In recent years, valuable experience and insights have been gained into L-forms (cell-wall-deficient variants) of bacteria fungi their disease-trigger potential in cases with chronic infections, autism spectrum disorders, autoimmune neurodegenerative diseases. Based on the concept “internal” blood microbiota, consisting its relevance to health disease, current study aims outline profile dysbiotic disorders three cancer patients (with endometrial cancer, breast acute myeloid leukemia), all a phase before chemotherapy. Venous samples from one control healthy person, were microbiologically studied. The used novel methodology microbiota assessment was based following phases: isolation L-forms, development propagation, cultivation conversion classical fungi, as well identification MALDI-TOF method. From isolated opportunistic (Enterococcus faecalis, Esherichia coli, Enterobacter cloacae Pseudomonas oryzihabitans) such Rhodotorula mucilaginosa, Aspergillus fumigatus Mucorales. conclusion, common feature found for highly associated communities morphologically indistinguishable L-bodies, which through reversion broth, identified distinct bacterial fungal species. Unlike classic or causing sepsis bacteremia/fungemia, presence is hidden, it does not demonstrate clinical signs nor can be detected by conventional methods. It should noted, however, that shows unique individual characteristics concrete patient, correlates state organism tumor localization body, outlines promoting role processes malignization, genesis progression.